The immune system of a person plays a vital function in his life. It protects you from various diseases allowing a person to live with minimal discomfort. Your immune system wards off agents that are harmful to man's health. There are times though that it is weakened and diseases invade ones body. During these times you will have to rely on interventions that are able to help improve your body's defenses. There are several measures that you can take so that you are able to improve health. There are cases though that you will have to suppress your immune function and liposomal clodronate is one of several ways to do so.
Well functioning immune systems are able to distinguish the cells that belong to the same host from the cells that are foreign to it. The defenses of your body coexist with cells which they are able to recognize as being from one host. If there are foreign cells encountered, immune response is launched keeping your body from any harm it can cause.
An example would be viruses that cause various diseases. There are treatments also that your immune system might reject such as for tissue transplants. That is because tissues that are from another's body also carry markers that your immune system will not recognize as your own.
Sometimes, the body will also be attacking its own. This happens for those with autoimmune disorders. The defenses of your body mistake the tissues in it to be a foreign one and will launch defenses against it. Diseases and some medications will predispose one to such condition or it could also be genetic.
Organisms are protected form infections through the immune system's layered defenses. There are physical barriers that protect the body from pathogens. When these barriers are breached, your innate immune system will provide with an immediate response. This response is nonspecific. When this proves insufficient, your innate immune response will trigger action of your adaptive immune system which has specific response per pathogen. This response will be retained allowing for a faster and stronger response when again encountered.
An important component of your immune system are macrophages. They are a type of white blood cells that functions in both innate and adaptive immunity. Their role will be engulfing pathogens and then digesting them.
Liposomes are artificially prepared vesicles that are made up by a lipid bilayer. They are used as vehicles for administration of nutrients and drugs. They are used in encapsulating molecules that are strongly hydrophilic like clodronate. Free clodronate does not easily pass bilayers of liposomes so that after it is delivered it would not be escaping the cell. Once the phospholipids are destroyed the drug is then released into the targeted cell. The cell is then killed through apoptosis.
This effectively eliminates macrophages. There will then be no cells that are going to attack tissues that are intentionally introduced to your body. Cells which attack the host's own body also get eliminated.
This is helpful in medicine. Strides are made to provide better treatment options. One of which is liposomal clodronate.
Well functioning immune systems are able to distinguish the cells that belong to the same host from the cells that are foreign to it. The defenses of your body coexist with cells which they are able to recognize as being from one host. If there are foreign cells encountered, immune response is launched keeping your body from any harm it can cause.
An example would be viruses that cause various diseases. There are treatments also that your immune system might reject such as for tissue transplants. That is because tissues that are from another's body also carry markers that your immune system will not recognize as your own.
Sometimes, the body will also be attacking its own. This happens for those with autoimmune disorders. The defenses of your body mistake the tissues in it to be a foreign one and will launch defenses against it. Diseases and some medications will predispose one to such condition or it could also be genetic.
Organisms are protected form infections through the immune system's layered defenses. There are physical barriers that protect the body from pathogens. When these barriers are breached, your innate immune system will provide with an immediate response. This response is nonspecific. When this proves insufficient, your innate immune response will trigger action of your adaptive immune system which has specific response per pathogen. This response will be retained allowing for a faster and stronger response when again encountered.
An important component of your immune system are macrophages. They are a type of white blood cells that functions in both innate and adaptive immunity. Their role will be engulfing pathogens and then digesting them.
Liposomes are artificially prepared vesicles that are made up by a lipid bilayer. They are used as vehicles for administration of nutrients and drugs. They are used in encapsulating molecules that are strongly hydrophilic like clodronate. Free clodronate does not easily pass bilayers of liposomes so that after it is delivered it would not be escaping the cell. Once the phospholipids are destroyed the drug is then released into the targeted cell. The cell is then killed through apoptosis.
This effectively eliminates macrophages. There will then be no cells that are going to attack tissues that are intentionally introduced to your body. Cells which attack the host's own body also get eliminated.
This is helpful in medicine. Strides are made to provide better treatment options. One of which is liposomal clodronate.
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